How generative AI designs proteins from scratch: the RFdiffusion denoising pipeline, ProteinMPNN sequence design, AlphaFold validation, and wet-lab loop.
How DeepMind AlphaProteo designs de novo protein binders — diffusion + structure prediction, target-conditioning, in vitro hit rates, and the 2026 outlook for AI-designed therapeutics.
AlphaFold 3 architecture explained: the Pairformer, the diffusion module, how it predicts proteins, DNA, RNA, ligands and complexes, and its accuracy and limits in 2026.